Circadian sensitivity to the cardiac glycoside oleandrin is associated with diurnal intestinal P-glycoprotein expression

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Molecular Pharmacology, Medicine, P-glycoprotein Gene +6

Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo

Bin Fang, Logan J. Everett, Jennifer Jager et al. · Cell · 2014 · 271 citations · Full text

Rhythmic Gene Transcription, Chromatin, Transcriptional Regulation +10

Are MDCK Cells Transfected with the Human MDR1 Gene a Good Model of the Human Intestinal Mucosa?

Fuxing Tang, Kazutoshi Horie, Ronald T. Borchardt · Pharmaceutical Research · 2002 · 212 citations · Full text

Are Mdck Cells, Human Cell, Immunology +6

Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.

Sunil K. Manna, Nand K. Sah, Robert A. Newman et al. · PubMed · 2000 · 187 citations

Chemoprevention Strategy, Molecular Regulation, Tnf-induced Nf-kappab Activation +26

Regulation of circadian clock transcriptional output by CLOCK:BMAL1

Alexandra J. Trott, Jérôme S. Menet · PLoS Genetics · 2018 · 173 citations · Full text

Genetics, Epigenetics, Transcriptional Regulation +17