Concepedia

Primary Human Natural Killer Cells Retain Proinflammatory IgG1 at the Cell Surface and Express CD16a Glycoforms with Donor-dependent Variability

Kashyap Patel, Joel D. Nott, Adam W. Barb

Molecular & Cellular Proteomics · 2019 · 37 citations · 59 references

DOIFull text

Open access

Concepts

Abstract

serum from the same donors (89.7 ± 3.9%). Thus, NK cells express CD16a with unique modification patterns and preferentially bind IgG1 without the Fc fucose modification at the cell surface.

References

59

Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene

Guillaume Cartron, Laurent Dacheux, Gilles Salles et al. · Blood · 2002 · 1.9K citations · Full text

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Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity

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Specificity and affinity of human Fcγ receptors and their polymorphic variants for human IgG subclasses

Pierre Bruhns, Bruno Iannascoli, Patrick England et al. · Blood · 2008 · 1.5K citations · Full text

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The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular Cytotoxicity

Toyohide Shinkawa, Kazuyasu Nakamura, Naoko Yamane et al. · Journal of Biological Chemistry · 2003 · 1.4K citations · Full text

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Two Immunoglobulin G Fragment C Receptor Polymorphisms Independently Predict Response to Rituximab in Patients With Follicular Lymphoma

Wen‐Kai Weng, Ronald Levy · Journal of Clinical Oncology · 2003 · 1.3K citations

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