Concepedia

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD

Jason Karch, Michael J. Bround, Hadi Khalil, Michelle A. Sargent, Nadina Latchman, Naohiro Terada, Pablo M. Peixoto, Jeffery D. Molkentin

Science Advances · 2019 · 243 citations · 25 references

DOIFull text

Open access

Concepts

Abstract

triple null mouse embryonic fibroblasts showed a loss of MPTP activity. Our findings suggest a model for the MPTP consisting of two distinct molecular components: The ANTs and an unknown species requiring CypD.

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