Jason Karch

Genetic lineage tracing defines myofibroblast origin and function in the injured heart

Onur Kanisicak, Hadi Khalil, Malina J. Ivey et al. · Nature Communications · 2016 · 876 citations · Full text

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

Hadi Khalil, Onur Kanisicak, Vikram Prasad et al. · Journal of Clinical Investigation · 2017 · 871 citations · Full text

Inflammation, Tgf-β Receptors Tgfbr1/2, Heart Failure +15

c-kit+ cells minimally contribute cardiomyocytes to the heart

Jop H. van Berlo, Onur Kanisicak, Marjorie Maillet et al. · Nature · 2014 · 789 citations · Full text

Cardiac Muscle, Cardiomyopathy, Heart Failure +8

Cyclophilin D controls mitochondrial pore–dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice

John W. Elrod, Renee Wong, Shikha Mishra et al. · Journal of Clinical Investigation · 2010 · 369 citations · Full text

Cardiac Muscle, Heart Failure, Cell Death +25

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

Jason Karch, Jennifer Q. Kwong, Michelle A. Sargent et al. · eLife · 2013 · 279 citations · Full text

Outer Membrane Permeability, Apoptosis, Immunology +16