Concepedia

A phase II randomized clinical trial of the effect of metformin versus placebo on progression-free survival in women with metastatic breast cancer receiving standard chemotherapy

Isabel Pimentel, Ana Elisa Lohmann, Marguerite Ennis, Ryan J.O. Dowling, David W. Cescon, Christine Elser, Kylea Potvin, Rashida Haq, Caroline Hamm, Martin C. Chang,

The Breast · 2019 · 101 citations · 12 references

DOI

Concepts

References

12

Metformin and reduced risk of cancer in diabetic patients

Josie Evans, Louise A. Donnelly, Alistair Emslie‐Smith et al. · BMJ · 2005 · 2.4K citations · Full text

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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Reuben J. Shaw, Katja Lamia, Debbie S. Vasquez et al. · Science · 2005 · 1.9K citations

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Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

Heather A. Hirsch, Dimitrios Iliopoulos, Philip N. Tsichlis et al. · Cancer Research · 2009 · 1.1K citations · Full text

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Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

Vladimir N. Anisimov, Lev M. Berstein, Peter A. Egormin et al. · Experimental Gerontology · 2005 · 400 citations

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Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Xu Huang, Stephan Wullschleger, Natalia Shpiro et al. · Biochemical Journal · 2008 · 393 citations · Full text

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