Deep Learning-Based Parkinson’s Disease Classification Using Vocal Feature Sets

Abstract

Parkinson's Disease (PD) is a progressive neurodegenerative disease with multiple motor and non-motor characteristics. PD patients commonly face vocal impairments during the early stages of the disease. So, diagnosis systems based on vocal disorders are at the forefront on recent PD detection studies. Our study proposes two frameworks based on Convolutional Neural Networks to classify Parkinson's Disease (PD) using sets of vocal (speech) features. Although, both frameworks are employed for the combination of various feature sets, they have difference in terms of combining feature sets. While the first framework combines different feature sets before given to 9-layered CNN as inputs, whereas the second framework passes feature sets to the parallel input layers which are directly connected to convolution layers. Thus, deep features from each parallel branch are extracted simultaneously before combining in the merge layer. Proposed models are trained with dataset taken from UCI Machine Learning repository and their performances are validated with Leave-One-Person-Out Cross Validation (LOPO CV). Due to imbalanced class distribution in our data, F-Measure and Matthews Correlation Coefficient metrics are used for the assessment along with accuracy. Experimental results show that the second framework seems to be very promising, since it is able to learn deep features from each feature set via parallel convolution layers. Extracted deep features are not only successful at distinguishing PD patients from healthy individuals but also effective in boosting up the discriminative power of the classifiers.