Concepedia

Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake

Alice E. Adriaenssens, Emma K. Biggs, Tamana Darwish, John A. Tadross, Tanmay Sukthankar, Milind Girish, Joseph Polex-Wolf, Ilona Zvetkova, Warren W. Pan, Davide Chiarugi,

Cell Metabolism · 2019 · 306 citations · 51 references

DOIFull text

Open access

Concepts

Abstract

-DREADDs in hypothalamic Gipr cells suppressed food intake in vivo, which was not obviously additive with concomitant GLP1R activation. These data identify hypothalamic GIPR as a target for the regulation of energy balance.

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