Neurokinin 1 receptor antagonists exhibit peripheral effects in prurigo nodularis including reduced <scp>ERK</scp>1/2 activation

Abstract

Our data confirm that NK1R antagonists such as aprepitant exhibit effects in the skin. Epidermal receptor expression, epidermal inflammatory ILs, ERK1/2 MAPK signalling and cutaneous inflammatory infiltrate were targets of NK1R antagonism. This may explain partly the antipruritic effect of NK1R antagonists next to its role in the central nervous system.