Journal of Materials Chemistry B · 2019 · 24 citations · 22 references
MedicineOncologyPharmaceuticsBiomedical ImagingChemotherapyMolecular ImagingCancer NanomedicineCombination ChemotherapyMultimodal ImagingNanocarriers For TherapeuticsNanomedicinePositron Emission TomographyDual-modality ImagingMultifunctional NanoplatformsNanoparticle Contrast AgentsNanoparticle Imaging AgentsNanoparticle-based ChemotherapyNanoparticle-based Contrast AgentsNanoparticle-mediated ImagingTheranostic Nanomaterials
ions. Both doxorubicin (DOX) and simvastatin (SV) were encapsulated in the core of the nanoparticles. The cell viability and combination index were evaluated in vitro. The tumor accumulation of the nanoparticles was investigated by positron-emission tomography (PET) and magnetic resonance (MR) imaging. The as-prepared nanoparticles exhibited high drug loading capacity. The drug loaded nanoparticles could kill cancer cells effectively with a combination index <1. Both PET and MRI revealed that the nanoparticles showed long blood circulation time and high tumor accumulation. The nanoparticles could inhibit tumor inhibition via intravenous injection of nanoparticles. The polyphenol-based nanoplatform may serve as a promising theranostic candidate for clinical application.
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Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2017 · 15K citations · Full text
Twan Lammers, Silvio Aime, Wim E. Hennink et al. · Accounts of Chemical Research · 2011 · 853 citations