Nanaomycins, new antibiotics produced by a strain of Streptomyces. II. Structure and biosynthesis.

Abstract

Evidence is put forward which describes the structure and stereochemistry of new antibiotics, nanaomycins A and B, as I and V, respectively. In order to study biosynthesis and to determine the position of the hydroxyl group in the naphthoquinone moiety, a feeding experiment with 1-13C-acetate was effectively carried out. Nanaomycins A and B were found to be synthesized from acetate via a polyketide by Streptomyces rosa var. notoensis.