ASP2397 Is a Novel Natural Compound That Exhibits Rapid and Potent Fungicidal Activity against <i>Aspergillus</i> Species through a Specific Transporter

Abstract

Current therapies against invasive pulmonary aspergillosis (IPA) have a limited cure rate. Given that a delay in treatment initiation may be fatal, a new drug with rapid-onset and potent fungicidal activity is needed. The novel cyclic hexapeptide ASP2397 (currently known as VL-2397) exhibited antifungal activity against Aspergillus fumigatus (including azole-sensitive and azole-resistant isolates), A. terreus , and A. flavus at an MIC range of 1 to 4 μg/ml in human serum.