Concepedia

Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold

Annalisa Reale, Simone Brogi, Alessia Chelini, Marco Paolino, Angela Di Capua, Germano Giuliani, Andrea Cappelli, Gianluca Giorgi, Giulia Chemi, Alessandro Grillo,

Bioorganic & Medicinal Chemistry · 2019 · 28 citations · 47 references

Open access

Concepts

Molecular PharmacologyMedicinal Chemistry1,5-Diarylpyrrol-3-substituted ScaffoldBiochemistryMedicineNatural SciencesSulfone DerivativesPharmacotherapyAnti-cancer AgentDrug DevelopmentPharmacologyMolecular ModelingPharmaceutical ChemistryDrug Discovery

References

47

A short history of<i>SHELX</i>

George M. Sheldrick · Acta Crystallographica Section A Foundations of Crystallography · 2007 · 86.8K citations · Full text

Shelx System, Engineering, Molecular Biology +14

Crystal structure refinement with<i>SHELXL</i>

George M. Sheldrick · Acta Crystallographica Section C Structural Chemistry · 2014 · 41.1K citations · Full text

X-ray Crystallography, Materials Science, Crystal Structure +13

Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy

Richard A. Friesner, Jay L. Banks, Robert B. Murphy et al. · Journal of Medicinal Chemistry · 2004 · 9.6K citations

Semianalytical treatment of solvation for molecular mechanics and dynamics

W. Clark Still, Anna Tempczyk, Ronald C. Hawley et al. · Journal of the American Chemical Society · 1990 · 3.6K citations

Engineering, Chemical Analysis, Altmetric Attention Score +16

Gastrointestinal Toxicity With Celecoxib vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis

Fred E. Silverstein, Gerald A. Faich, Jay L. Goldstein et al. · JAMA · 2000 · 3.2K citations