A classification system for split-hand/ foot malformation (SHFM): A proposal based on 3 pedigrees with WNT10B mutations

Fgf8 signalling from the AER is essential for normal limb development

Mark Lewandoski, Xin Sun, Gail R. Martin · Nature Genetics · 2000 · 459 citations

Life Sciences, Developmental Biology, Molecular Biology +12

Increasing<i>Fgf4</i>expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of<i>Fgf8</i>function

Pengfei Lu, George Minowada, Gail R. Martin · Development · 2005 · 94 citations · Full text

Life Sciences, Developmental Biology, Genetics +15

Identification of a novel <i>DLX5</i> mutation in a family with autosomal recessive split hand and foot malformation

Hanan E. Shamseldin, Maha Faden, Walid Alashram et al. · Journal of Medical Genetics · 2011 · 83 citations

Life Sciences, Genetics, Molecular Genetics +17

Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation

Aslıhan Tolun · Human Molecular Genetics · 2008 · 81 citations

Medicine, Genetics, Molecular Genetics +17

Exome sequencing and CRISPR/Cas genome editing identify mutations of <i>ZAK</i> as a cause of limb defects in humans and mice

Malte Spielmann, Naseebullah Kakar, Naeimeh Tayebi et al. · Genome Research · 2016 · 62 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17