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ApoC-III Glycoforms Are Differentially Cleared by Hepatic TRL (Triglyceride-Rich Lipoprotein) Receptors

DOIFull Paper Access

34

Citations

38

References

2019

Year

Natalie C. Kegulian, Bastian Ramms, Steven Horton, Olgica Trenchevska, Dobrin Nedelkov, Mark J. Graham, Richard Lee, Jeffrey D. Esko, Hussein N. Yassine, Philip L.S.M. Gordts
Arteriosclerosis Thrombosis and Vascular Biology

Abstract

Our results indicate that HSPGs preferentially clear apoC-III<sub>2</sub>. In contrast, apoC-III<sub>1</sub> is more effectively cleared by LDLR/LRP1. Clinically, the increase in the apoC-III<sub>2</sub>/apoC-III<sub>1</sub> ratio on antisense lowering of apoC-III might reflect faster clearance of apoC-III<sub>1</sub> because this metabolic shift associates with improved triglyceride levels.

References

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