Concepedia

Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes

Hong Zhou, Caixia Fang, Lihui Zhang, Yong-gui Deng, Mian Wang, Meng Fengling

Chinese Medical Journal · 2014 · 34 citations · 22 references

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Abstract

Fasudil ameliorates liver fibrosis in rats with type 2 diabetes at least partly by inhibiting TGFβ1/CTGF pathway and α-SMA expression. Inhibition of RhoA/ROCK may be a novel therapeutic target for liver fibrosis in diabetic non-alcoholic steatohepatitis.

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