Journal of Toxicology · 2019 · 52 citations · 15 references
PharmacyPharmacologyToxicologyBiochemical ToxicologyPharmaceutical ToxicologyReproductive ToxicologyGenotoxicity AssessmentGenotoxicity MechanismsGenotoxicity TestingMutagenicity AssessmentToxic PlantsToxicology AssessmentChromosomal Aberration DetectionHerbal ToxicityLeaf Extract AssaysToxic Dose AssessmentToxicity BioassaysToxicity Testing Of PlantsToxicological EvaluationToxicology Of Medicinal Plants
) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw). A 90-day repeated dose oral toxicity study was conducted in rats using doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg bw/day. Based on the lack of mortality or toxic effects in the 90-day study, the NOAEL for MLE in Han:Wist male and female rats was determined to be 2000 mg/kg bw/day, the highest dose tested.
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KA Shah, MB Patel, RJ Patel et al. · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · 2010 · 429 citations · Full text