Concepedia

Pharmacokinetics and Penetration of Sitafloxacin into Alveolar Epithelial Lining Fluid in Critically Ill Thai Patients with Pneumonia

Taniya Paiboonvong, Wichit Nosoongnoen, Korbtham Sathirakul, Viratch Tangsujaritvijit, Jaipak Kaemapairoj, Pramote Tragulpiankit, Preecha Montakantikul

Antimicrobial Agents and Chemotherapy · 2019 · 11 citations · 8 references

DOI

Concepts

Abstract

Sitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio of epithelial lining fluid (ELF) to unbound plasma concentration was 1.02 ± 0.58 (1.33).

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