Concepedia

DNA binding preferences of S. cerevisiae RNA polymerase I Core Factor reveal a preference for the GC-minor groove and a conserved binding mechanism

Ashleigh J. Jackobel, Brian J. Zeberl, Danea Glover, Aula M. Fakhouri, Bruce A. Knutson

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · 2019 · 10 citations · 86 references

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86

Elevated recombination rates in transcriptionally active DNA

Barbara J. Thomas, Rodney Rothstein · Cell · 1989 · 1.6K citations

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Co-crystal structure of TBP recognizing the minor groove of a TATA element

Joseph L. Kim, Dimitar B. Nikolov, S.K. Burley · Nature · 1993 · 1K citations

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Multiple Forms of DNA-dependent RNA Polymerase in Eukaryotic Organisms

Robert G. Roeder, William J. Rutter · Nature · 1969 · 963 citations

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Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

Denis Drygin, Amy Lin, Josh Bliesath et al. · Cancer Research · 2010 · 621 citations

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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

Hong Xu, Marco Di Antonio, Steven McKinney et al. · Nature Communications · 2017 · 588 citations · Full text

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