Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma - Concepedia

Concepedia

Publication | Open Access

Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma

DOI Full Paper Access

43

Citations

30

References

2019

Year

Weiyi Peng, Leila J. Williams, Chunyu Xu, Brenda Melendez, Jodi A. McKenzie, Yuan Chen, Heather L. Jackson, Kui Shin Voo, Rina M. Mbofung, Sara Elizabeth Leahey,

Clinical Cancer Research

Abstract

These results highlight a critical role of OX40 activation in potentiating the effector function of tumor-reactive CD8<sup>+</sup> T cells and suggest further evaluation of OX40 agonist-based combinations in patients with immune-resistant tumors.

References

	Year	Citations

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