Organic Letters · 2019 · 15 citations · 51 references
Natural SciencesChemistryCatalysisCombinatorial ChemistryOrganic ChemistryCombinatorial SynthesisCross-coupling ReactionsDiversity-oriented SynthesisHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisC-h ActivationFused Heterocycle SynthesisHeterocycle FunctionalizationIndole ChemistryIndole SynthesisRing-forming Reactions
A Rh(III)-catalyzed undirected C-H activation/alkene insertion to synthesize diversified indole-fused polycyclics has been developed. Intramolecular electrophilic cyclization generated a 3-indolyl rhodium species that went through an aryl-to-aryl 1,4-rhodium migration to realize the C-H activation. The subsequent [4 + 2] carboannulation or hydroarylation of alkenes could be achieved, respectively, by simply adjusting the additives of the reaction.
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Efficient catalytic addition of aromatic carbon-hydrogen bonds to olefins
Shinji Murai, Fumitoshi Kakiuchi, Shinya Sekine et al. · Nature · 1993 · 1.4K citations
Biotinylated Rh(III) Complexes in Engineered Streptavidin for Accelerated Asymmetric C–H Activation
Todd K. Hyster, Livia Knörr, Thomas R. Ward et al. · Science · 2012 · 806 citations · Full text