Abnormalities of mucosal serotonin metabolism and 5‐HT<sub>3</sub> receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron - Concepedia

Concepedia

Publication | Open Access

Abnormalities of mucosal serotonin metabolism and 5‐HT<sub>3</sub> receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron

DOI Full Paper Access

43

Citations

28

References

2019

Year

David Gunn, Klara Garsed, Ching Lam, Gulzar Singh, Melanie Lingaya, Verena Wahl, Beate Niesler, Amanda P. Henry, Ian P. Hall, Peter J. Whorwell

Alimentary Pharmacology & Therapeutics

Abstract

IBS-D patients have significant abnormalities in mucosal 5-HT metabolism. Those with the lowest concentration of 5-HT in rectal biopsies showed the greatest responsiveness to ondansetron.

References

	Year	Citations

Page 1