Concepedia

Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112

Meng Bai, Guo‐Lei Huang, Rong-Qing Mei, Bin Wang, You‐Ping Luo, Xu‐Hua Nong, Guang‐Ying Chen, Cai‐Juan Zheng

Marine Drugs · 2019 · 33 citations · 23 references

DOIFull text

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Abstract

Three new lactones penicilactones A-C (<b>1</b>-<b>3</b>) were obtained from the mangrove-derived fungus <i>Penicillium</i> sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo<sub>2</sub>(OAc)<sub>4</sub>-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound <b>1</b> showed antibacterial activity against <i>Staphylococcus aureus</i> with an MIC value of 6.25 μg/mL. Compound <b>2</b> showed insecticidal activity against newly hatched larvae of <i>Culex quinquefasciatus</i> with the LC<sub>50</sub> value of 78.5 (±0.58) μg/mL.

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