Design, synthesis, and biological evaluation of matrine derivatives possessing piperazine moiety as antitumor agents

Antitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagy

Junqiang Zhang · World Journal of Gastroenterology · 2010 · 133 citations · Full text

Design and synthesis of anti-breast cancer agents from 4-piperazinylquinoline: A hybrid pharmacophore approach

V. Raja Solomon, Changkun Hu, Hoyun Lee · Bioorganic & Medicinal Chemistry · 2010 · 130 citations

Combinatorial Chemistry, Medicinal Chemistry, Medicine +8

Matrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3

Zhijun Dai, Jie Gao, Ji Zongzheng et al. · Journal of Ethnopharmacology · 2009 · 108 citations

Matrine Induces Apoptosis, Chemoprevention Strategy, Apoptosis +7

Determination of 1-aryl-4-propylpiperazine pKa values: The substituent on aryl modulates basicity

Enza Lacivita, Marcello Leopoldo, Paola De Giorgio et al. · Bioorganic & Medicinal Chemistry · 2008 · 47 citations

1-Aryl-4-propylpiperazine Pka Values, Biochemistry, Medicine +5

Antioxidative activities of novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter

Makoto Kimura, Tomoko Masuda, Koji Yamada et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 45 citations

Antioxidative Activities, Biochemistry, Dopamine Transporter +8