Concepedia

Management of Anti‐drug Antibodies to Biologic Medications in Children With Inflammatory Bowel Disease

Reuven Zev Cohen, Bess T. Schoen, Subra Kugathasan, Cary G. Sauer

Journal of Pediatric Gastroenterology and Nutrition · 2019 · 26 citations · 15 references

DOI

Abstract

With limited therapies for IBD and the chronicity of the disease, we advocate salvage of the current anti-TNF through dose optimization in pediatric patients with antibody level <10 U/mL.

References

15

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Induction and Maintenance Infliximab Therapy for the Treatment of Moderate-to-Severe Crohn’s Disease in Children

Jeffrey S. Hyams, Wallace Crandall, Subra Kugathasan et al. · Gastroenterology · 2006 · 859 citations

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Cynthia H. Seow, Alvin Newman, Sue P. Irwin et al. · Gut · 2009 · 532 citations