Concepedia

Fatty acid-induced CD36 expression via O-GlcNAcylation drives gastric cancer metastasis

Mingzuo Jiang, Nan Wu, Bing Xu, Yi Chu, Xiaowei Li, Song Su, Di Chen, Wenjiao Li, Yanting Shi, Xiaoliang Gao,

Theranostics · 2019 · 144 citations · 30 references

DOIFull text

Open access

Concepts

Abstract

: FA-induced hyper-O-GlcNAcylation promotes the transcription and function of CD36 by activating the NF-κB pathway and directly modifying CD36 at S468 and T470, which drives GC metastasis.

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