Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2

Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans

Takao Watanabe, Hiroyuki Kusuhara, Kazuya Maeda et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 350 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

The risk of herpes zoster in patients with rheumatoid arthritis in the United States and the United Kingdom

Allison Smitten, Hyon K. Choi, Marc C. Hochberg et al. · Arthritis Care & Research · 2007 · 282 citations · Full text

Medicine, Internal Medicine, Pharmacotherapy +12

Functional Involvement of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in the Renal Elimination of the Antiviral Drugs Adefovir and Tenofovir

Tomoki Imaoka, Hiroyuki Kusuhara, Masashi Adachi et al. · Molecular Pharmacology · 2006 · 280 citations

Medicine, Pharmacokinetics, Pharmacology +17

Clinical Pharmacokinetics of Leflunomide

B Rozman · Clinical Pharmacokinetics · 2002 · 247 citations

Pharmacy, Clinical Pharmacokinetics, Pharmacokinetics +10

Species Difference in the Inhibitory Effect of Nonsteroidal Anti-Inflammatory Drugs on the Uptake of Methotrexate by Human Kidney Slices

Yoshitane Nozaki, Hiroyuki Kusuhara, Tsunenori Kondo et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 157 citations

Medicine, Pharmacokinetics, Pharmacology +17