Synthesis of Pyridine Derivatives from Acetophenone and Ammonium Acetate by Releasing CH₄

Abstract

Abstract An efficient copper‐catalyzed cyclization of acetophenone and ammonium acetate with release of methane has been developed for the synthesis of polysubstituted pyridines. A series of 2,4,6‐triphenyl‐pyridines has been produced in good yields. This synthetic method is sustainable, simple, and environment‐friendly.