Concepedia

The mutational spectrum of FLT3 gene in acute lymphoblastic leukemia is different from acute myeloid leukemia

Yu Zhang, Yang Zhang, Fang Wang, Mingyu Wang, Hong Liu, Xue Chen, Panxiang Cao, Xiaoli Ma, Wen Teng, Xian Zhang,

Cancer Gene Therapy · 2019 · 26 citations · 25 references

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25

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

Yukiya Yamamoto · Blood · 2001 · 1.1K citations

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Acute Myeloid Leukemia, Version 3.2017, NCCN Clinical Practice Guidelines in Oncology

Margaret O’Donnell, Martin S. Tallman, Camille N. Abboud et al. · Journal of the National Comprehensive Cancer Network · 2017 · 655 citations · Full text

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Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation

Cheuk Him Man, Tsz Kan Fung, Christa Ho et al. · Blood · 2012 · 278 citations · Full text

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FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications

Susan P. Whitman, Amy S. Ruppert, Michael D. Radmacher et al. · Blood · 2007 · 267 citations · Full text

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Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 “Gatekeeper” F691L Mutation with PLX3397

Catherine C. Smith, Chao Zhang, Kimberly C. Lin et al. · Cancer Discovery · 2015 · 203 citations · Full text

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