Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation

Cheuk Him Man, Tsz Kan Fung, Christa Ho, +9

Blood

Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis

Yiping Wang, Azeem Sharda, Shuangnian Xu, +6

Cell Metabolism

BiosynthesisCellular EnzymologyBiochemistryMitochondrial FunctionNatural Sciences +5

Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia

Cheuk Him Man, Tsz Kan Fung, Haixia Wan, +9

Blood

Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia

Bai‐Liang He, Xiangguo Shi, Cheuk Him Man, +8

Blood

A novel tescalcin-sodium/hydrogen exchange axis underlying sorafenib resistance in FLT3-ITD+ AML

Cheuk Him Man, Stephen S.Y. Lam, Murphy Ka Hei Sun, +4

Blood

Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth

Cheuk Him Man, François Mercier, Nian Liu, +7

Blood

Loss of sphingosine kinase 2 promotes the expansion of hematopoietic stem cells by improving their metabolic fitness

Changzheng Li, Binghuo Wu, Yishan Li, +21

Blood

Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML

Cheuk Him Man, Wing Lam, Chee-Chean Dang, +16

Blood

Mixed-phenotype Acute LeukemiaEpigenetic ChangeImmunologyEpigeneticsMyeloid Neoplasia +14

Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish

Xiangguo Shi, Bai‐Liang He, C. H. Alvin, +8

Blood

SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression

W. Yan, Chengmei Xie, Sijun Sun, +12

The EMBO Journal