Biophysical modeling and experimental validation of relative biological effectiveness (RBE) for 4He ion beam therapy

Abstract

Existing phenomenological and mechanistic/biophysical models were successfully integrated and validated in both Monte Carlo and GPU-accelerated analytical platforms against in vitro experiments, and tested using pristine peaks and clinical fields in highly radio-resistant tissues where models exhibit the greatest RBE uncertainty. Together, these efforts mark an important step towards clinical translation of raster-scanning ⁴He ion beam therapy to the clinic.