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Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part I. Mechanistic modelling of drug product dissolution to derive a P-PSD for PBPK model input

Vivo ExposureBiochemistryMedicineDrug Product DissolutionToxicologyVitro DissolutionPharmacologyPhysiologically-based Pharmacokinetic ModelingPharmacokinetics