Journal of Cellular Physiology · 2019 · 29 citations · 23 references
MedicineMolecular BiologyOncologyCarcinogenesisGene ExpressionMolecular OncologyCancer Cell SignalingMicrorna-mediated RegulationNoncoding Rna In CancerOncogenic ProliferationOncogenic Signaling PathwaysThyroid CancerLong Noncoding Rna RegulationMicrorna Function In CancerMicrorna In CancerMicrorna ModulationMicrorna-mediated OncogenesisNoncoding Rna-mediated Gene RegulationOncogenic Noncoding RnaOncogenic Transformation
Emerging evidence has indicated that long noncoding RNA (lncRNAs) play crucial roles in regulating thyroid cancer (TC) development. Linc00210 is a newly identified lncRNA which plays an oncogenic role in hepatocellular carcinoma and nasopharyngeal carcinoma, but whether Linc00210 can modulate the development of TC remains elusive. Here, we found that Linc00210 expression was upregulated in TC tissues compared to the matched noncancerous tissues. Overexpression of Linc00210 augmented the proliferation, migration, and invasion of TC cells. Mechanistically, Linc00210 served as a sponge for miR-195-5p, thereby counteracting its ability in downregulating the expression of IGF1R and the activation of PI3K/Akt signaling. Moreover, inhibition of Linc00210 suppressed the growth of TC cells in nude mice. Our findings for the first time uncovered the oncogenic property of Linc00210 in TC.
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Annual report on status of cancer in China, 2011.
Wanqing Chen, Rongshou Zheng, Hongmei Zeng et al. · PubMed · 2015 · 379 citations