Abstract 3174: A novel prognostic model for tongue squamous cell carcinoma based on the characteristics of tumor and its microenvironment: iBD score

Abstract

Aims: Tumor budding and invasive depth can predict survival of patients with tongue squamous cell carcinoma (TSCC), while the prognostic value of tumor microenvironment (TME) remains unknown. Here, both characteristics of tumor and its microenvironment were examined and a novel prognostic model has been proposed.Methods: A total of 246 patients with TSCC were included. Using H&E stained sections, pathological parameters of tumor and the TME were assessed. Inflammatory response (i), tumor budding (B), and invasive depth (D) were combined as iBD score. The association between these variables and the patient survival was determined.Results: Both tumor budding and inflammatory status were independent variables for predicting overall survival (OS) and disease-free survival (DFS) of TSCC patients. Invasive depth was correlated with differentiation, T classification, lymph node metastasis, clinical stage, and recurrence (P< 0.05). The novel iBD model was strongly correlated with T classification, lymph node metastasis, clinical stage, and recurrence, and showed clear distinction of score 0, 1 and 2. High iBD score had a strong association with reduced OS and DFS (P< 0.01).Conclusions: iBD scoring model is strongly associated with lymph node metastasis and recurrence in TSCC and could be a promising survival predictor for TSCC patients.Note: This abstract was not presented at the meeting.Citation Format: Xiqiang Liu. A novel prognostic model for tongue squamous cell carcinoma based on the characteristics of tumor and its microenvironment: iBD score [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3174.