Asymmetric Synthesis of 4-Substituted 2,6-Dioxopiperidine-3-carbonitrile by Using Thiourea-Catalyzed Asymmetric Michael Addition

Abstract

An enantioselective Michael addition of several α,β-unsaturated carbonyl compounds with malononitrile catalyzed by a bifunctional thiourea is described.We also demonstrate the transformation of Michael adduct into an enantiomerically enriched functionalized piperidine.