Cyclization Reactions of 1,1-Bis(trimethylsilyloxy)ketene Acetals

Abstract

1,1-Bis(trimethylsilyloxy)ketene acetals represent useful synthetic building blocks that can be regarded as masked carboxylic acid dianions. In recent years, a number of cyclization reactions of 1,1-bis(trimethylsilyloxy)ketene acetals have been reported that provide a convenient synthesis of various pharmacologically relevant heterocyclic products. 1 Introduction 2 Synthesis of Lactones 3 Synthesis of Cyclic Anhydrides 4 Synthesis of Lactone-Bridged N-Heterocycles 5 Synthesis of Lactone-Annulated N-Heterocycles 6 Conclusions 7 Acknowledgment