A convenient and efficient synthesis of C-carbamoyl-1,2,3-triazoles from alkyl bromide by a one-pot sequential addition: conversion of ester to amide using Zr(Ot-Bu)4

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition · 2002 · 11.5K citations

Natural Sciences, Chemistry, Catalysis +8

Peptidotriazoles on Solid Phase:  [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides

Christian W. Tornøe, Caspar Christensen, Morten Meldal · The Journal of Organic Chemistry · 2002 · 8.5K citations

Pharmacy, Medicinal Chemistry, Catalysis +12

Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition

Qian Wang, Timothy R. Chan, Robert Hilgraf et al. · Journal of the American Chemical Society · 2003 · 1.6K citations

Natural Sciences, Biochemistry, Chemistry +12

Efficiency and Fidelity in a Click‐Chemistry Route to Triazole Dendrimers by the Copper(<scp>I</scp>)‐Catalyzed Ligation of Azides and Alkynes

Peng Wu, Alina K. Feldman, Anne K. Nugent et al. · Angewandte Chemie International Edition · 2004 · 1.2K citations

Natural Sciences, Chemistry, Medicinal Chemistry +9

Activity-Based Protein Profiling in Vivo Using a Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition

Anna E Speers, Gregory C. Adam, Benjamin F. Cravatt · Journal of the American Chemical Society · 2003 · 948 citations

Life Sciences, Biochemistry, Molecular Biology +17