Journal of Synthetic Organic Chemistry Japan · 1999 · 30 citations · 1 references
Natural SciencesChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisOrganic SynthesisRetrosynthetic AnalysisAsymmetric Heterocycle SynthesisAsymmetric SynthesisMedicinal Chemistry ApplicationsNatural Product Total SynthesisTotal Synthesis-derived Analogues
New approaches to total asymmetric synthesis of ircinal A and manzamine A are described. The synthesis utilizes a highly efficient Diels-Alder reaction of the suitably functionalized dihydropyridinones and siloxydienes as a key step, followed by expedient conversion to manzamine A.
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Masahide Tanaka, Hiroshi Mitsuhashi, Masao Maruno et al. · Chemistry Letters · 1994 · 21 citations