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Regioselective Dealkylation of 2-Alkoxybenzoic Acid and Its Amide Derivatives with Aliphatic Amines
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2000
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Chemical EngineeringCross-coupling ReactionEngineeringCleavage ReactionEnantioselective SynthesisDerivative (Chemistry)Regioselective DealkylationAmide DerivativesOrganic ChemistryChemistryPharmacologyAsymmetric CatalysisChemical DerivativeSynthetic ChemistryAliphatic AminesO-anisic Acid
The methoxy group of o-anisic acid was cleaved with aliphatic amines in aprotic dipolar solvents. This cleavage reaction was especially smooth when piperazine in dimethylacetamide was used. This method was applicable to a variety of dealkylations of o-alkoxybenzoic acid and its amide derivatives with high regioselectivity.