Additive Effects on Asymmetric Hydrogenation of N-Heteroaromatics

Abstract

The multiplication of chiral information is one of the most important tasks in organic chemistry.Chiral catalysis is the most elegant way to achieve this and organic chemists developed a variety of catalytic asymmetric reaction systems, in which the addition of some chemicals effectively improves the performance of transition-metal-catalysis.In this review, we summarize development of additive effects in the asymmetric hydrogenation of N-heteroaromatic compounds based on interactions of additives with catalysts and substrates.