Synthesis of 4-alkyl-pyrrolidine-3-carboxylic acid stereoisomers

A synthetic method for formyl→ethynyl conversion (RCHO→RCCH or RCCR′)

E. J. Corey, P.L. Fuchs · Tetrahedron Letters · 1972 · 1.6K citations

Natural Sciences, Chemical Engineering, Chemistry +7

The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium Channel

N S Gee, Jason P. Brown, Visaka U.K. Dissanayake et al. · Journal of Biological Chemistry · 1996 · 1.2K citations · Full text

Medicine, Neuroscience, Pharmacology +15

Asymmetric Diels-Alder cycloaddition reactions with chiral .alpha.,.beta.-unsaturated N-acyloxazolidinones

David A. Evans, Kevin T. Chapman, John J. Bisaha · Journal of the American Chemical Society · 1988 · 635 citations

Natural Sciences, Chemistry, Organic Chemistry +6

Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat

Mark J. Field, Scott McCleary, John Hughes et al. · Pain · 1999 · 299 citations

Medicine, Neuroscience, Pharmacology +10

Practical synthesis of Z-unsaturated esters by using a new Horner-Emmons reagent, ethyl diphenylphosphonoacetate

Kaori Ando · Tetrahedron Letters · 1995 · 195 citations

Natural Sciences, Chemistry, Organic Chemistry +1