Synthesis and Antitubercular Evaluation of <i>N</i>‐Arylpyrazine and <i>N,N′</i>‐Alkyl‐diylpyrazine‐2‐carboxamide Derivatives

Abstract

Two series of pyrazinamide (PZA) derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. Some compounds exhibited minimum inhibitory concentration activity of 50–100 μg/mL, greater than the first line antituberculosis drug PZA in Alamar Blue assay (&gt;100 μg/mL). The obtained activities can be considered promising results, which characterizes these compounds as good start points to development of new antitubercular agents.