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The Horner-Wadsworth-Emmons Reaction in Natural Products Synthesis: Expedient Construction of Complex (<i>E</i>)-Enones Using Barium Hydroxide
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1993
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Cross-coupling ReactionEnantioselective SynthesisNatural Products SynthesisEngineeringNatural SciencesDiversity-oriented SynthesisOrganic ChemistryStereoselective SynthesisChemistryBase-sensitive AldehydesNatural Product SynthesisSynthetic ChemistryBarium HydroxideBiomolecular EngineeringHorner-wadsworth-emmons Reaction
The barium hydroxide promoted Horner-Wadsworth-Emmons reaction is a mild and efficient method for the coupling of ß-ketophosphonates with structurally complex, base-sensitive aldehydes in equimolar quantities to give (E)-enones.