Heterocycles · 2001 · 10 citations · 6 references
Life SciencesMolecular BiologyPharmacologyCell SignalingMolecular PharmacologySignal TransductionCardiovascular Molecular PhysiologyCyclic Nucleotide SignalingG Protein-coupled Receptor SignalingCyclic Guanosine Monophosphate PathwayNitric OxideNitric Oxide BiologyNitric Oxide SignalingPhotoaffinity ProbesSoluble Guanylate Cyclase Stimulators
A new route to the soluble guanylate cyclase (sGC) activator YC-1 and its N2 regioisomer has been established with a Mitsunobu mediated Nalkylation as the key step.The route is utilised in the synthesis of a potential photoaffinity label.sGC is the only physiological receptor for nitric oxide (NO) discovered hitherto.NO is a pleiotropic signalling molecule with widespread effects in both the cardiovascular and central nervous system. 1 NO
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