Transmetalation of <i>Z</i>-Telluroenynes: Stereoselective Synthesis of <i>Z</i>-Enynols and Their Application in Palladium-Catalyzed Cyclization

Abstract

The synthesis of various Z-enynols via reaction of vinyllithium intermediate with aldehydes and ketones is described. The subsequent cyclization of a wide variety of Z-enynols afforded substituted furans and dihydrofurans with high regioselectivity under mild reaction conditions.