Synlett · 2012 · 23 citations · 0 references
Natural SciencesChemistryMedicinal ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsRetrosynthetic AnalysisAromatic Ring ExpansionAzetidine ChemistryCarbodiimide-mediated CouplingHeterocyclic Ring ExpansionOxazole ChemistryOxazole Synthesis
Ring expansion of keto aziridines to the corresponding 2,5-diaryl oxazoles in the presence of dicyclohexyl carbodiimide and iodine under refluxing acetonitrile conditions is described. A plausible mechanism is proposed.