Stereospecific Synthesis of Chalcogenoenynes by Palladium-Catalyzed Cross-Coupling Reaction

Abstract

A new methodology for the synthesis of chalcogenoenynes is described. The palladium-catalyzed cross-coupling reaction of 1,2-bis(organanylchalcogeno)-alkenes and 1-alkynes gave the corresponding chalcogenoenynes in 71% to 88% yields. Preliminary pharmacologycal tests suggest that chalcogenoenynes may be useful drugs as anti-inflammatory and antinociceptive agents.