5-Arylidene-3-aryl-pyrrolidine-2,4-diones with Affinity to theN-Methyl-D-aspartate (Glycine Site) Receptor, Part I - Concepedia

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5-Arylidene-3-aryl-pyrrolidine-2,4-diones with Affinity to theN-Methyl-D-aspartate (Glycine Site) Receptor, Part I

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References

1998

Year

Hermann Poschenrieder, Georg Höfner, Hans‐Dietrich Stachel

Archiv der Pharmazie

Molecular PharmacologyGlycine SiteBiochemistryG Protein-coupled ReceptorMedicineBinding AffinityReceptor (Biochemistry)New 5-Arylidene 3-Aryl-pyrrolidine-2,4-dionesNon-peptide LigandMolecular RecognitionPharmacologyDrug Discovery

Abstract

A series of new 5-arylidene 3-aryl-pyrrolidine-2,4-diones has been prepared. Their binding affinity toward the N-methyl-D-aspartate (glycine site) receptor has been measured as a basis for more detailed structure-activity relationship studies.