A New and Facile Synthesis of Thieno[2,3-b]indole Derivatives via Condensation of Isocyanide and Indolin-2-thiones - Concepedia

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A New and Facile Synthesis of Thieno[2,3-b]indole Derivatives via Condensation of Isocyanide and Indolin-2-thiones

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2009

Year

Firouz Matloubi Moghaddam, Zohreh Mirjafary, Salman Taheri, Somayyeh Kheirjou

HeterocyclicNew One-pot SynthesisFacile SynthesisDiversity-oriented SynthesisNatural Sciencesα-Halocarbonyl CompoundsOrganic ChemistryCyclohexyl IsocyanideChemistryNatural Product SynthesisDerivative (Chemistry)Synthetic ChemistryEnantioselective Synthesis

Abstract

A new one-pot synthesis of thieno[2,3-b]indole ring systems is described. Condensation of cyclohexyl isocyanide with indolin-2-thiones yielded 3-cyclohexyaminomethylene-indolin-2-thiones, which upon reaction with α-halocarbonyl compounds produced the title compounds.