arXiv (Cornell University) · 2013 · 66 citations · 35 references
Natural SciencesBioinformaticsBiostatisticsComputational BiologyStatistical ModelingStatisticsBayesian InferenceBayesian StatisticsInferential StatisticsNetwork InferenceProbability DistributionsStatistical InferenceConditional DistributionsExponential Family DistributionsGaussian Graphical ModelsGraphical ModelsIsing ModelMarkov Network ModelsNegative Binomial DistributionNegative Binomial Models
Undirected graphical models, or Markov networks, are a popular class of statistical models, used in a wide variety of applications. Popular instances of this class include Gaussian graphical models and Ising models. In many settings, however, it might not be clear which subclass of graphical models to use, particularly for non-Gaussian and non-categorical data. In this paper, we consider a general sub-class of graphical models where the node-wise conditional distributions arise from exponential families. This allows us to derive multivariate graphical model distributions from univariate exponential family distributions, such as the Poisson, negative binomial, and exponential distributions. Our key contributions include a class of M-estimators to fit these graphical model distributions; and rigorous statistical analysis showing that these M-estimators recover the true graphical model structure exactly, with high probability. We provide examples of genomic and proteomic networks learned via instances of our class of graphical models derived from Poisson and exponential distributions.
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Mapping and quantifying mammalian transcriptomes by RNA-Seq
A Mortazavi, Brian A. Williams, Kenneth McCue et al. · Nature Methods · 2008 · 14.3K citations
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High dimensional graphs and variable selection with the Lasso
2006 · 2.7K citations