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A Solvent- and Metal-Free Synthesis of 3-Chacogenyl-indoles Employing DMSO/I<sub>2</sub>as an Eco-friendly Catalytic Oxidation System
188
Citations
54
References
2014
Year
Chemical EngineeringMetal-free SynthesisEngineeringNovel OrganocatalystsMetal-free MethodMolecular IodineOrganic ChemistryCatalysisMolecular CatalysisChemistryHeterocycle ChemistryNatural Product SynthesisSynthetic ChemistryCatalytic SynthesisEquivalent Amount
Herein, we describe a solvent- and metal-free method for the synthesis of 3-chalcogenyl-indoles from indoles and diorganyl dichalcogenides using an equivalent amount of DMSO as an oxidant, under catalysis by molecular iodine. This mild and eco-friendly approach allowed the preparation of a wide range of 3-selenyl- and 3-sulfenyl-indoles in good to excellent yields.
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